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even further illuminating issues, operate and therapeutic efficacy of MSCs are hugely controlled because of the bordering specialized niche/microenvironment (Zhu et al., 2016; Mehrbani Azar et al., 2018; Tejero et al., 2019; Gilchrist et al., 2021), and reports on skeletal degenerative and autoimmune disorders have highlighted the essence of ce
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